Posted 13 June, 2026
Post-Doctoral Researcher School of Engineering and Architecture
University Vacancies Ireland
Cork, Cork, Ireland
Temporary
Reference: 1140804510
A Post-Doctoral Researcher is sought to work on a project supported by the SFI on a 2-year contract starting from October 2024. The Post-Doctoral Researcher will be responsible for the development of platform for the crystallisation of anti-sense oligonucleotides. The successful candidate is expected to have Ph.D. in Chemistry, Pharmaceutical Science, Crystal Engineering, Chemical Engineering, or related disciplines and experience in development of crystallisation method of pharmaceutical and biopharmaceuticals, solubility analysis, solving crystal structures, understanding molecular dynamics simulations software's such as Material Studio, LAMPPS, etc., and meticulous knowledge of analytical tools used in the pharmaceutical industry.
The successful candidate will be hosted at the Process and Chemical Engineering Department. For more details see https://www.ucc.ie/en/processeng/
Project Summary
Antisense oligonucleotides (ASO) are novel alternative gene therapeutics with the potential to target diseases at the molecular level. The purification and isolation steps of ASO production generate the maximum waste, making the process unsustainable, creating a demand for greener and more economical routes. This project envisions developing a template-assisted crystallisation protocol to produce ASO crystals with improved handling and processing properties. The aim is to develop a generalised protocol that can be used for a broad variety of ASOs differing due to their nucleotide sequence, and to use this protocol to crystallise a marketed ASO drug.
Application Instructions
For an information package including full details of the post, selection criteria and application process see https://ore.ucc.ie/ The University, at its discretion, may undertake to make an additional appointment(s) from this competition following the conclusion of the process.
Informal enquiries can be made in confidence to Dr Vivek Verma, Lecturer, Process and Chemical Engineering Department; Tel: + 353 (0) 21 4902549 Email: [email protected]
For further information on the Department: Engineering and Architecture | University College Cork
Document
Candidate Brief_541.pdf 2.77 MB
Apply
The successful candidate will be hosted at the Process and Chemical Engineering Department. For more details see https://www.ucc.ie/en/processeng/
Project Summary
Antisense oligonucleotides (ASO) are novel alternative gene therapeutics with the potential to target diseases at the molecular level. The purification and isolation steps of ASO production generate the maximum waste, making the process unsustainable, creating a demand for greener and more economical routes. This project envisions developing a template-assisted crystallisation protocol to produce ASO crystals with improved handling and processing properties. The aim is to develop a generalised protocol that can be used for a broad variety of ASOs differing due to their nucleotide sequence, and to use this protocol to crystallise a marketed ASO drug.
Application Instructions
For an information package including full details of the post, selection criteria and application process see https://ore.ucc.ie/ The University, at its discretion, may undertake to make an additional appointment(s) from this competition following the conclusion of the process.
Informal enquiries can be made in confidence to Dr Vivek Verma, Lecturer, Process and Chemical Engineering Department; Tel: + 353 (0) 21 4902549 Email: [email protected]
For further information on the Department: Engineering and Architecture | University College Cork
Document
Candidate Brief_541.pdf 2.77 MB
Apply
