Posted 12 June, 2026
Research Fellow (Postdoctoral Researcher)
Trinity College Dublin
Dublin, Dublin, Ireland
Full Time
Reference: 876135360
Trinity is Ireland's leading university and is ranked 75th in the world (QS World University Rankings 2026). Founded in 1592, the University is steeped in history with a reputation for excellence in education, research, and innovation, which has been inspiring generations of thinkers for over 400 years. Thrive: Trinity College Dublin's Strategic Plan 2025 - 2030
The Ryan Lab investigates how pathogenic mitochondrial DNA mutations influence innate immune function, inflammatory responses, cellular metabolism, and susceptibility to infection. The lab uses primary macrophage models, mouse models of mitochondrial disease, immunological assays, metabolic phenotyping, molecular biology, and multi-omics approaches to understand how inherited mitochondrial defects reshape innate immune signalling and inflammatory disease susceptibility.
This postdoctoral role will focus on defining how pathogenic mitochondrial DNA mutations alter macrophage function, innate immune signalling, type I interferon responses, inflammatory cytokine production, cellular metabolism, and responses to inflammatory or infectious stimuli. The postholder will work with ex vivo primary macrophage systems derived from mitochondrial disease models and will integrate wet-lab immunology, mitochondrial biology, molecular biology, metabolism, and in vivo-linked sample workflows.
The role would suit a motivated postdoctoral researcher with experience in immunology, mitochondrial biology, metabolism, infection biology, inflammatory disease, molecular biology, or a related area, who is seeking to develop an independent research profile within mitochondrial immunometabolism.
Application Procedure
Applicants should submit a full Curriculum Vitae plus a short cover letter to include the names and contact details of 2 referees (including email addresses), to:-
Dr. Dylan Ryan
[email protected]
Please use the subject line: Postdoctoral Research Fellow Application - Ryan Lab.
The cover letter should briefly outline the candidate's relevant research experience, interest in the research area, motivation for applying, and how their expertise aligns with the role.
Our Values - putting our words into action
Values matter. They are key to the success of our Strategic Plan. We centre our behavioural values around the importance of belonging. We recognise that the university will thrive by each of us respecting and caring for one another. We know we can achieve much more through working together. We know too that we must take responsibility for our actions and be accountable. We must, and will never stop, imagining. And through being nature positive we connect not just with the environment but with our ambitions for a sustainable future.
At Trinity, we are committed to equality, diversity, and inclusion. Trinity welcomes applications from all individuals, including those applicants with disabilities, those who may have had non-traditional career paths, those who have taken time out for reasons including family or caring responsibilities. We also welcome international applicants including those who have been displaced due to war.
Trinity College Dublin is Ireland's premier University. We are an EU Sustainable Gender Equality Champion and we hold an Athena Swan Silver award, recognising our ongoing work to advance gender equality both within Trinity and in the Higher Education sector. Trinity is committed to supporting work-life balance and to creating a family-friendly working environment.
The Ryan Lab investigates how pathogenic mitochondrial DNA mutations influence innate immune function, inflammatory responses, cellular metabolism, and susceptibility to infection. The lab uses primary macrophage models, mouse models of mitochondrial disease, immunological assays, metabolic phenotyping, molecular biology, and multi-omics approaches to understand how inherited mitochondrial defects reshape innate immune signalling and inflammatory disease susceptibility.
This postdoctoral role will focus on defining how pathogenic mitochondrial DNA mutations alter macrophage function, innate immune signalling, type I interferon responses, inflammatory cytokine production, cellular metabolism, and responses to inflammatory or infectious stimuli. The postholder will work with ex vivo primary macrophage systems derived from mitochondrial disease models and will integrate wet-lab immunology, mitochondrial biology, molecular biology, metabolism, and in vivo-linked sample workflows.
The role would suit a motivated postdoctoral researcher with experience in immunology, mitochondrial biology, metabolism, infection biology, inflammatory disease, molecular biology, or a related area, who is seeking to develop an independent research profile within mitochondrial immunometabolism.
Application Procedure
Applicants should submit a full Curriculum Vitae plus a short cover letter to include the names and contact details of 2 referees (including email addresses), to:-
Dr. Dylan Ryan
[email protected]
Please use the subject line: Postdoctoral Research Fellow Application - Ryan Lab.
The cover letter should briefly outline the candidate's relevant research experience, interest in the research area, motivation for applying, and how their expertise aligns with the role.
Our Values - putting our words into action
Values matter. They are key to the success of our Strategic Plan. We centre our behavioural values around the importance of belonging. We recognise that the university will thrive by each of us respecting and caring for one another. We know we can achieve much more through working together. We know too that we must take responsibility for our actions and be accountable. We must, and will never stop, imagining. And through being nature positive we connect not just with the environment but with our ambitions for a sustainable future.
At Trinity, we are committed to equality, diversity, and inclusion. Trinity welcomes applications from all individuals, including those applicants with disabilities, those who may have had non-traditional career paths, those who have taken time out for reasons including family or caring responsibilities. We also welcome international applicants including those who have been displaced due to war.
Trinity College Dublin is Ireland's premier University. We are an EU Sustainable Gender Equality Champion and we hold an Athena Swan Silver award, recognising our ongoing work to advance gender equality both within Trinity and in the Higher Education sector. Trinity is committed to supporting work-life balance and to creating a family-friendly working environment.
