Posted 12 June, 2026
Research Fellow (Postdoctoral Researcher)
University Vacancies Ireland
Dublin, Dublin, Ireland
Temporary
Reference: 1757182111
Post Status: Full-time; Specific Purpose
Research Group / Department / School: Ryan Lab, School of Biochemistry and Immunology, Trinity College Dublin, the University of Dublin
Location: Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland
Reports to: Dr. Dylan Ryan
Salary: Appointment will be made on the PD1 scale at a point in line with Government Pay Policy and commensurate with experience. The starting salary range is €47,273 - €52,513 per annum, and appointment will be made no higher than point 5.
Hours of Work: 39 hours per week Flexible start date, Ideally 1st September 2026
Closing Date: 12 Noon (GMT), 26 JUNE 2026
Post Summary:
Context:
The Ryan Lab investigates how pathogenic mitochondrial DNA mutations influence innate immune function, inflammatory responses, cellular metabolism, and susceptibility to infection. The lab uses primary macrophage models, mouse models of mitochondrial disease, immunological assays, metabolic phenotyping, molecular biology, and multi-omics approaches to understand how inherited mitochondrial defects reshape innate immune signalling and inflammatory disease susceptibility.
This postdoctoral role will focus on defining how pathogenic mitochondrial DNA mutations alter macrophage function, innate immune signalling, type I interferon responses, inflammatory cytokine production, cellular metabolism, and responses to inflammatory or infectious stimuli. The postholder will work with ex vivo primary macrophage systems derived from mitochondrial disease models and will integrate wet-lab immunology, mitochondrial biology, molecular biology, metabolism, and in vivo-linked sample workflows.
The role would suit a motivated postdoctoral researcher with experience in immunology, mitochondrial biology, metabolism, infection biology, inflammatory disease, molecular biology, or a related area, who is seeking to develop an independent research profile within mitochondrial immunometabolism.
Role summary:
The Postdoctoral Research Fellow will lead a defined research project within the Ryan Lab's Wellcome Trust Career Development Award programme. The postholder will design, conduct, analyse, and interpret experiments investigating how pathogenic mitochondrial DNA mutations alter innate immune responses, inflammatory signalling, and cellular metabolism.
The role will initially involve substantial wet-lab work using ex vivo macrophage models, including primary mouse bone marrow-derived macrophages and associated innate immune cell systems and in vivo infection studies. Experimental approaches may include primary cell culture, immune stimulation and infection-associated assays, cytokine measurements, qPCR, immunoblotting, flow cytometry, confocal microscopy, Seahorse metabolic analysis, mitochondrial phenotyping, and sample preparation for transcriptomic, proteomic, metabolomic, or other omics-based workflows.
The postholder will also contribute to mouse model-linked workflows, including experimental planning, tissue collection, sample processing, genotyping coordination, cohort planning, and integration of ex vivo and in vivo datasets. They will work closely with Dr. Dylan Ryan, research assistants, PhD students, technical staff, collaborators, and animal facility staff to deliver highquality, ethical, reproducible research.
This is a full-time role that will primarily be based on-site at TBSI due to the hands-on laboratory, animal-model-linked, and collaborative nature of the work. Some flexibility may be available for data analysis, writing, planning, and administrative tasks where compatible with experimental schedules, team needs, animal welfare requirements, and institutional policies.
Qualifications
Essential
• A PhD, or PhD thesis submitted, in immunology, mitochondrial biology, metabolism, infection biology, inflammatory disease, molecular biology, cell biology, biochemistry, genetics, biomedical sciences, or a related discipline.
Application Instructions
Please click on the Apply button below for the full job description and application instructions.
Apply
Research Group / Department / School: Ryan Lab, School of Biochemistry and Immunology, Trinity College Dublin, the University of Dublin
Location: Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland
Reports to: Dr. Dylan Ryan
Salary: Appointment will be made on the PD1 scale at a point in line with Government Pay Policy and commensurate with experience. The starting salary range is €47,273 - €52,513 per annum, and appointment will be made no higher than point 5.
Hours of Work: 39 hours per week Flexible start date, Ideally 1st September 2026
Closing Date: 12 Noon (GMT), 26 JUNE 2026
Post Summary:
Context:
The Ryan Lab investigates how pathogenic mitochondrial DNA mutations influence innate immune function, inflammatory responses, cellular metabolism, and susceptibility to infection. The lab uses primary macrophage models, mouse models of mitochondrial disease, immunological assays, metabolic phenotyping, molecular biology, and multi-omics approaches to understand how inherited mitochondrial defects reshape innate immune signalling and inflammatory disease susceptibility.
This postdoctoral role will focus on defining how pathogenic mitochondrial DNA mutations alter macrophage function, innate immune signalling, type I interferon responses, inflammatory cytokine production, cellular metabolism, and responses to inflammatory or infectious stimuli. The postholder will work with ex vivo primary macrophage systems derived from mitochondrial disease models and will integrate wet-lab immunology, mitochondrial biology, molecular biology, metabolism, and in vivo-linked sample workflows.
The role would suit a motivated postdoctoral researcher with experience in immunology, mitochondrial biology, metabolism, infection biology, inflammatory disease, molecular biology, or a related area, who is seeking to develop an independent research profile within mitochondrial immunometabolism.
Role summary:
The Postdoctoral Research Fellow will lead a defined research project within the Ryan Lab's Wellcome Trust Career Development Award programme. The postholder will design, conduct, analyse, and interpret experiments investigating how pathogenic mitochondrial DNA mutations alter innate immune responses, inflammatory signalling, and cellular metabolism.
The role will initially involve substantial wet-lab work using ex vivo macrophage models, including primary mouse bone marrow-derived macrophages and associated innate immune cell systems and in vivo infection studies. Experimental approaches may include primary cell culture, immune stimulation and infection-associated assays, cytokine measurements, qPCR, immunoblotting, flow cytometry, confocal microscopy, Seahorse metabolic analysis, mitochondrial phenotyping, and sample preparation for transcriptomic, proteomic, metabolomic, or other omics-based workflows.
The postholder will also contribute to mouse model-linked workflows, including experimental planning, tissue collection, sample processing, genotyping coordination, cohort planning, and integration of ex vivo and in vivo datasets. They will work closely with Dr. Dylan Ryan, research assistants, PhD students, technical staff, collaborators, and animal facility staff to deliver highquality, ethical, reproducible research.
This is a full-time role that will primarily be based on-site at TBSI due to the hands-on laboratory, animal-model-linked, and collaborative nature of the work. Some flexibility may be available for data analysis, writing, planning, and administrative tasks where compatible with experimental schedules, team needs, animal welfare requirements, and institutional policies.
Qualifications
Essential
• A PhD, or PhD thesis submitted, in immunology, mitochondrial biology, metabolism, infection biology, inflammatory disease, molecular biology, cell biology, biochemistry, genetics, biomedical sciences, or a related discipline.
Application Instructions
Please click on the Apply button below for the full job description and application instructions.
Apply
